High-dose flu vaccine tied to lower Alzheimer’s risk in older adults

Fri, 3 Apr 2026 10:51:05 +1100

Andrew Pam <xanni [at] glasswings.com.au>

Andrew Pam
<https://www.cidrap.umn.edu/influenza-vaccines/high-dose-flu-vaccine-tied-lower-alzheimer-s-risk-older-adults>

"Receiving a high-dose flu vaccine is associated with a significantly lower
risk of Alzheimer’s disease than a standard-dose vaccine in adults aged 65 and
older, according to a large observational study published in Neurology. The
findings add to a growing body of evidence linking vaccination, and possibly
immune system activity, to reduced dementia risk.

In the retrospective cohort study, researchers led by a team at the McGovern
Medical School at UTHealth in Houston analyzed health data from roughly 165,000
older adults who received either a high-dose or standard-dose influenza
vaccine. The researchers found that the high-dose flu vaccine reduced the risk
of Alzheimer’s disease in those 65 and older by nearly 55% over a roughly
two-year period.

Previous findings by the same research team found the standard-dose vaccine was
tied to a 40% reduced risk of developing Alzheimer’s over a four-year period.

The high-dose influenza vaccine contains four times the antigen (the component
that generates an immune response) of standard-dose vaccines. The Centers for
Disease Control and Prevention recommends that all adults 65 years and older
receive the high-dose vaccine."

Cheers,
       *** Xanni ***
--
mailto:xanni@xanadu.net               Andrew Pam
http://xanadu.com.au/                 Chief Scientist, Xanadu
https://glasswings.com.au/            Partner, Glass Wings
https://sericyb.com.au/               Manager, Serious Cybernetics

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